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Antiviral drug discovery and development: challenges and future directions - Signal Transduction and Targeted Therapy
2+ hour, 16+ min ago (1591+ words) The development and application of neuraminidase (NA) inhibitors, such as oseltamivir53,54,55 and zanamivir,56,57,58 have provided potent tools for the treatment and prevention of influenza, particularly in managing influenza pandemics. The rational computer-aided design of zanamivir heralded a new era in the…...
Dynamic antigen expression and cytotoxic T cell resistance in HIV reservoir clones
1+ day, 2+ hour ago (195+ words) These authors contributed equally: Isabella A. T. M. Ferreira, Alberto Herrera Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York, USA Immunology and Microbial Pathogenesis Program, Weill Cornell Medicine, New York, NY, USA Laboratory of Molecular Immunology, The Rockefeller…...
B cells maintain the homeostasis of splenic marginal zone antigen-presenting cells to promote the antiviral CD8+ T-cell response - Cellular & Molecular Immunology
1+ day, 2+ hour ago (1785+ words) Cellular & Molecular Immunology (2026)Cite this article JHT mice were adoptively transferred with mouse serum derived from normal C57BL/6 mice and mouse serum derived from MCMV-infected C57BL/6J mice 3 weeks after infection. The transfer started three days before infection, followed by one serum transfer…...
Comparative analysis of deep mutational scanning datasets in enteroviruses A and B identifies functional divergence and therapeutic targets - Nature Ecology & Evolution
1+ day, 16+ hour ago (1700+ words) Nature Ecology & Evolution (2026)Cite this article Comparison of the standardized datasets revealed striking similarities between the two DMS datasets despite the divergence of EVA and EVB (Fig. 1e and Supplementary Fig. 2b,c), as evidenced by the strong correlation of the average MFE…...
This giant virus hijacks cells’ protein-making machinery to multiply wildly
6+ day, 8+ hour ago (380+ words) Scientists report that a type of giant virus multiplies furiously by hijacking its host's protein-making machinery1 " long-sought experimental evidence that viruses can co-opt a system typically associated with cellular life. The researchers found that the virus makes a complex of three…...
Microsoft team creates 'revolutionary' data storage system that lasts for millennia
6+ day, 13+ hour ago (402+ words) Microscoft's glass storage method can store 4.8 terabytes of data.Credit: Microsoft Research Researchers at Microsoft have created a data-storage system that can remain readable for at least 10,000 years " and probably much longer. The Microsoft team used a high-energy laser to…...
Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat’s body surface - Scientific Reports
6+ day, 19+ hour ago (1355+ words) Detection of cat housekeeping gene mRNA from body surface lipids (BSLs). Four BSL samples were collected from three cats. Data show the mean'SD of triplicate measurements from one assay, representative of at least three independent experiments. As the final experiment,…...
Cooperative clamp-mediated promoter recognition by poxviral RNA polymerase and its TBP/TFIIB-like partner - Nature Communications
6+ day, 21+ hour ago (1739+ words) We analyzed the purified vRNAP complex by means of cryo-EM. A dataset containing about 9 million particles allowed for a 2.4" reconstruction and building of an almost complete model (Fig.2A, Table1 for data collection, reconstruction and model refinement statistics; see also Supplementary Fig....
Laser-written glass tablets can preserve data for millennia
1+ week, 2+ hour ago (249+ words) Feng Chen is in the School of Physics, State Key Laboratory of Crystal Materials, Shandong University, Jinan 250100, China. Nature 650, 557-558 (2026) Glezer, E. N. et al. Opt. Lett. 21, 20232025 (1996). Shimotsuma, Y., Kazansky, P. G., Qiu, J. & Hirao, K. Phys. Rev. Lett. 91, 247405 (2003). Sun, K. et al. Science 375, 307310 (2022). Zhao, M. et al. Nature 626, 772778 (2024). Microsoft…...
Laser writing in glass for dense, fast and efficient archival data storage
1+ week, 2+ hour ago (1799+ words) Our work is based on several key innovations: Two efficient regimes of volume pixel (voxel) writing in glass: we use phase voxels relying on isotropic refractive index (RI) changes and birefringent voxels based on anisotropic changes (see section "Writing data)....