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Dynamic regulation of TBK1 lactylation shapes antiviral immune responses - Cellular & Molecular Immunology
1+ hour, 37+ min ago (1891+ words) Cellular & Molecular Immunology (2026)Cite this article All data are available in the main text or the supplementary materials. Roers A, Hiller B, Hornung V. Recognition of endogenous nucleic acids by the innate immune system. Immunity. 2016;44:73954. Choi Y, Bowman JW, Jung JU....
Disposable Point of Care multiplexed plasmonic biosensor for rapid and specific identification of respiratory viruses - npj Biosensing
11+ hour, 50+ min ago (1512+ words) As an alternative to molecular tests, rapid antigen tests (RATs) based on lateral-flow assays can be used at the point-of-care by non-specialized personnel and the end-user. These tests allow for the rapid ( According to these last conditions and the results…...
A giant virus forms a specialized subcellular environment within its amoeba host for efficient translation - Nature Microbiology
4+ day, 3+ hour ago (1722+ words) The average expression levels of viral mRNAs were higher than those of amoeba mRNAs at all time points (Fig. 1d). The expression levels of individual viral mRNAs increased gradually, whereas those of host mRNAs decreased throughout infection (Fig. 1d). Translation activity, evaluated…...
Characterisation of the tilapia lake virus proteome and identification of an 11th protein, S9-F3
4+ day, 13+ hour ago (1759+ words) npj Viruses volume4, Articlenumber:2 (2026) Cite this article To investigate nuclear export inhibition, LMB was used in a CRM1 inhibition assay. OmB and 293T cells were transfected with S9 and S9-F3 expression constructs (and controls) for 24h, followed by incubation with either 10nM LMB or dimethyl sulfoxide (DMSO;…...
Human cytomegalovirus-specific T-cell responses and immune-guided strategies as predictors of clinically significant infection in hematopoietic stem cell transplant recipients after letermovir prophylaxis
5+ day, 19+ hour ago (251+ words) The data that support the findings of this study are available on reasonable request from the corresponding author. Li CR, Greenberg PD, Gilbert MJ, Goodrich JM, Riddell SR. Recovery of HLA-restricted cytomegalovirus (CMV)-specific T-cell responses after allogeneic bone marrow transplant:…...
Expression and distribution of rAAV9 intrathecally administered in juvenile to adolescent mice
6+ day, 13+ hour ago (1740+ words) Gene Therapy (2026)Cite this article Female C57BL/6 mice (age: 6 weeks) were dosed with AAV9 vector at a local facility, Explora BioLabs (San Diego). The study was approved by the Institutional Animal Care and Use Committee (IACUC) at the testing facility, and procedures…...
Discovering the laws behind complex networked systems
1+ week, 1+ day ago (184+ words) A recent study shows that neural symbolic regression offers a route to automated discovery of governing equations for network dynamics across high-dimensional complex systems. Receive 12 digital issues and online access to articles only $9.92 per issue Wang, H. et al. Nature 620, 4760 (2023). Thibeault,…...
HIV disrupts the lung molecular clock, leading to lung inflammation and features of emphysema
1+ week, 1+ day ago (1733+ words) In the lung, the circadian rhythm regulates daily fluctuation in airway diameter, airway resistance, respiratory symptoms, mucus production, and inflammatory responses, which in turn contribute to the diurnal pattern of exacerbation frequency and occurrence14,15. The molecular clock operates through a negative…...
Structural insights into type-I and type-II Lamassu antiphage systems
1+ week, 4+ day ago (1277+ words) Nature Chemical Biology (2026)Cite this article Cryo-EM structures and atomic models generated in this study have been deposited in the wwPDB OneDep System under EMD accession codes EMD-64575, EMD-64576, EMD-64585, EMD-64586, EMD-64583 and EMD-64584 and PDB ID codes under accession…...
An efficient data driven framework for intrusion detection in wireless sensor networks using deep learning
2+ week, 11+ hour ago (1140+ words) Flow diagram of the proposed methodology. From Table 2 , it is observed that WSN-DS is an imbalanced dataset, where the number of samples in each category of classification differs. Let the intrusion detection dataset be denoted as expressed in Eq. (1). n…...